Evaluation of Oestrogen and Progesterone Receptors and c-erbB-2 in Carcinoma of the breast in Trinidadian Women

One hundred and three consecutive cases of breast cancer in Trinidadian women were evaluated for steriod receptor status and c-erB-2 receptor along with conventional parameters including age, ethnicity, tumour size, histological type and grade, and lymph node status: The molecular markers were studied by immunohistochemistry (IHC) on paraffin sections. Tumour size > 2 cm was seen in 60 percent of the cases. Oestrogen receptor (ER), progestrone receptor (PR) and c-erbB-2 showed 54 percent, 46 percent, and 63 percent positivity, respectively. There was no correlation between c-erbB-2 and steroid receptors. Forty-one percent of cases showed double negativity for steriod receptors (ER-/PR-). No correlation was found between the markers and conventional parameters except for a negative correlation with the tumour grade. The high percentage of c-erbB-2 positivity and the high propotion of steriod receptor negativity suggest a need for studies on adjuvant therapy. Integration of selected markers with conventional parameters could help define sub-groups for treatment and pragnosis (AU)

Evaluacion de regiones de organizacion nucleolar (NORs) en infiltrados linfocitarios cutaneos / Valuation of necleolar organizer region (NORs) in cutaneous lymphocytic infiltrates

Los NORs son segmentos del brazo corto de determinados cromosomas acrocentricos, que se ponen en evidencia mediante la tincion argentica. Se estudiaron 10 seudolinfomas cutaneos, 6 reaccion por artropodos, 4 linfadenosis cutaneas benignas, 4 linfomas no Hodgkin de bajo grado, 3 linfomas no Hodgkin de alto grado y especimenes con infiltrado cutaneo no especificos. Los resultados demostraron que el indice de Ag NORs es de utilidad para diferenciar linformas de bajo grado con los de alto grado de malignidad. Tambien es de utilidad en el diagnostico diferencial entre seudolinfomas y linfomas, sumado a otros parametros